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Section: Hemostasis
2.5 Hemostasis Problem Solving

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A standard blue-top tube filled appropriately (with 4.5 mL blood) was submitted to the laboratory for preoperative PT and APTT testing. The results of both tests were elevated. The patient’s PT and APTT from the previous day were within normal limits, and he is not on heparin therapy.
Which is the most appropriate first step to investigate the abnormal results?

Report the result as obtained
Perform a mixing study
Check the sample for a clot
Report the APTT only