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Section: Immunology
3.8 Immunology Problem Solving

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SITUATION: A 54-year-old man was admitted to the hospital after having a seizure. Many laboratory tests were performed, including an RPR, but none of the results were positive. The physician suspects a case of late (tertiary) syphilis. Which test should be performed next?
Repeat RPR, then perform VDRL
Treponemal test such as MHA-TP on serum
VDRL on CSF
No laboratory test is positive for late (tertiary) syphilis