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Section: Clinical Chemistry5.9 Toxicology and Therapeutic Drug Monitoring
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Which formula can be used to estimate dosage needed to give a desired steady-state blood level?
Dose per hour = clearance (milligrams per hour) × average concentration at steady state ÷ f
Dose per day = fraction absorbed – fraction excreted
Dose = fraction absorbed × (1/protein-bound fraction)
Dose per day = half-life × log V
d
(volume distribution)