Section 8.2
Molecular Diagnostics

How can cell proliferation be explained by the BCR/ABL gene rearrangement that occurs in the 9:22 translocation that causes the Ph¹ chromosome of CML?

It causes underexpression of p53 A hybrid protein is made that up-regulates the cell cycle Translocation induces a point mutation in the ABL oncogene ABL activates p23

Section 8.2Molecular Diagnostics

How can cell proliferation be explained by the BCR/ABL gene rearrangement that occurs in the 9:22 translocation that causes the Ph1 chromosome of CML?

Section 8.2
Molecular Diagnostics

How can cell proliferation be explained by the BCR/ABL gene rearrangement that occurs in the 9:22 translocation that causes the Ph¹ chromosome of CML?